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The results are consistent with the notion that domain II, which harbors most of the variability in primary structure, plays a crucial role in defining the substrate specificity of class mu isoenzymes

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Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G

SIRT1 regulates adipocyte differentiation, hepatic lipid metabolism, systemic inflammation, nutrient sensing, circadian rhythms, and particularly lipogenesis 29

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